Propanephosphonic Acid Anhydride (50% Solution In DMF)

Parth lcp
1 min readDec 13, 2023

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50 solution in DMF — Propylphosphonic anhydride is a highly reactive cyclic anhydride commonly used as a coupling agent and water scavenger.

Application

Coupling reagent for peptide synthesis; Preparation of other amides; Synthesis of esters (depsipeptides)

Features and Benefits

  • Some of its unique features include:
  • Broad functional group tolerance
  • Low epimerization tendency
  • By-products are water-soluble
  • High yield and purity

CAS No : 68957–94–8

EC Number : 422–210–5

PRODUCT SPECIFICATION

  • Grade technical
  • Quality Level 100
  • Form solution
  • Concentration ~50% in DMF
  • SMILES string CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1
  • InChI 1S/C9H21O6P3/c1–4–7–16(10)13–17(11,8–5–2)15–18(12,14–16)9–6–3/h4–9H2,1–3H3
  • InChI key PAQZWJGSJMLPMG-UHFFFAOYSA-N

SAFETY INFORMATION AS PER GHS

  • Hazard Classifications Eye Dam. 1 — Met. Corr. 1 — Repr. 1B — Skin Corr. 1B — Skin Sens. 1
  • Signal Word Danger
  • Storage Class Code 6.1C — Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
  • Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
  • Flash Point(C) 62 °C
  • Flash Point(F) 143.6 °F

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Parth lcp

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