Propanephosphonic acid anhydride
Propanephosphonic acid anhydride is an anhydride of propanephosphonic acid. Its structure is a cyclic trimer, with a phosphorus-oxygen core propyl groups, and additional oxygens attached.
The chemical is a useful reagent for peptide synthesis reactions, where it activates the carboxylic acid partner for subsequent reaction with amines. It is commercially available as a 50% solution in DMF or ethyl acetate as a slightly yellow mixture.
Molar mass: 318.182 g·mol−1
Chemical formula: C9H21O6P3
Hazard statements: H290, H314
PubChem CID: 111923
Precautionary Statements:
- Keep away from heat, hot surfaces, sparks, open flames, and other ignition sources. No smoking.
- Keep the container tightly closed.
- Keep only in original packaging.
- Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection.
IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present, and easy to do. Continue rinsing.
Signal Word — Danger
Storage class — 3 Flammable liquids
WGK — WGK 1 slightly hazardous to water
Disposal — 11 Organic acid halides, anhydrides, and isocyanates can be added dropwise to an excess of methanol (Cat. №822283) to convert them into the corresponding methyl esters or methyl carbamates.
If necessary, neutralize with sodium hydroxide solution (Cat. №105587).
Product Specification
- vapor pressure 97 hPa ( 20 °C)
- Quality Level 200
- Form Liquid
- Bp 77 °C/1013 hPa (ethyl acetate)
- Transition Temp flash point -4 °C (ethyl acetate)
- Density 1.08 g/cm3 at 20 °C
- Storage Temp 2–8°C
- Assay (NMR) ≥ 40.0 %
- Pyropropanephosphonic acid (NMR) ≤ 10.0 %
- Propanephosphonic acid (NMR) ≤ 0.50 %
- Ethyl acetate (calculated) ≤ 50.0 %
Safety Information As Per GHS
Hazard Statement :
- Highly flammable liquid and vapor.
- May be corrosive to metals.
- Causes severe skin burns and eye damage.
- May cause an allergic skin reaction.
- May cause drowsiness or dizziness.
Originally published at https://www.lifechempharma.com.
